晏彪,男,汉族,湖北汉川人,1988年7月出生。博士,讲师。长期从事环境医学和分子毒理学研究,中国环境诱变剂学会生物标志物专业委员会会员,咸宁市健康环境工程技术研究中心科研骨干。近年来,主持湖北省教育厅项目等5项;研究成果以第一作者或通讯作者在Sci Total Environ、Environ Pollut等TOP期刊发表论文9篇。主要揭示维生素E和尼莫地平拮抗塑化剂邻苯二甲酸酯诱导学习记忆障碍的信号通路及分子机制;应用液相色谱-串联质谱技术,整合生物信息学、微生物组学、代谢组学等多组学方法系统地揭示农药草甘膦对人群的膳食风险、毒性效应及益生菌消减毒性的重要机理。2016年获湖北省科技进步奖二等奖1项(个人排名第4)。
一、近五年主持或参加科研项目:
1. 湖北科技学院博士启动基金项目,BK202319,即刻早期基因c-fos/c-jun 介导孕期PAEs暴露致子鼠学习障碍的机制研究,2023/1-2026/12,20万元,在研,主持
2. 湖北省教育厅科学研究计划指导性项目,PAEs暴露致儿童智力障碍与内源性雌二醇靶向拮抗PAEs的作用研究,B2018172,2018/1-2019/12,结题,主持
3. 湖北科技学院校内培育项目,ERK1/2通过ROS-MAPK-ERK途径介导PAEs诱导脑海马细胞功能障碍的作用机制研究,2019-20X017,2019/1-2020/12,结题,主持
4. 湖北科技学院校内培育项目,邻苯二甲酸二丁酯诱导神经系统功能障碍的机制研究,2016-18X026,2017/1-2018/12,结题,主持
5. 国家自然科学基金面上项目,42177416,环境中邻苯二甲酸二丁酯诱发过敏性哮喘的神经-免疫正反馈调控机制,2022/01-2025/12,57万元,在研,参与
6. 湖北省卫生健康委重点支撑项目,WJ2021Z006,神经-免疫分子通路对邻苯二甲酸酯诱发的儿童过敏性哮喘的介导作用,2021/01-2022/12,10万元,在研,参与
7. 湖北省高等学校优秀中青年科技创新团队项目,T201717,增塑剂邻苯二甲酸酯的健康效应,2017/01-2020/12,20万元,已结题,参与
8. 湖北省卫生计生委重点支撑项目,WJ2017Z027,增塑剂邻苯二甲酸酯致机体氧化损伤及相关疾病的毒理学作用的研究,2017/01-2018/12,10万元,已结题,参与
二、代表性论文
1. Biao Yan, Jian Han, Yumiao Sun, Lei Lei, Jing Yuan, Zhixian Qiao, Jun Men, Xin Wang, Yongyong Guo, Qidong Wang, Bingsheng Zhou. Probiotics ameliorate growth retardation of glyphosate by regulating intestinal microbiota and metabolites in crucian carp (Carassius auratus). Science of the Total Environment, 2022, 851: 158260.
2. Biao Yan, Lei Lei, Xiangping Chen, Jun Men, Yumiao Sun, Yongyong Guo, Lihua Yang, Qidong Wang, Jian Han, Bingsheng Zhou. Glyphosate and glufosinate-ammonium in aquaculture ponds and aquatic products: Occurrence and health risk assessment. Environmental Pollution, 2022, 296: 118742.
3. Biao Yan, Ping Ma, Shaohui Chen, Hongguo Cheng, Min Tang, Yanling Sun, Xu Yang, Yang Wu, Menglin Cheng. Nimodipine attenuates dibutyl phthalate-induced learning and memory impairment in Kun ming mice: An in vivo study based on bioinformatics analysis. Environmental Toxicology, 2021, 36(5): 821-830.
4. Xianliang Wang, Xu Yan, Yuyan Yang, Wenjing Yang, Yujing Zhang, Jiao Wang, Dan Ye, Yang Wu, Ping Ma, Biao Yan. Dibutyl phthalate-mediated oxidative stress induces splenic injury in mice and the attenuating effects of vitamin E and curcumin. Food and Chemical Toxicology, 2020, 136: 110955.
5. Feng Liang, Biao Yan. Oxidative damage in the liver and kidney induced by dermal exposure to diisononyl phthalate in Balb/c mice. Toxicology and Industrial Health, 2020, 36(1): 30-40.
6. Biao Yan, Yanling Sun, Jie Zeng, Yingying Chen, Chongyao Li, Peng Song, Lin Zhang, Xu Yang, Yang Wu, Ping Ma. Combined use of vitamin E and nimodipine ameliorates dibutyl phthalate-induced memory deficit and apoptosis in mice by inhibiting the ERK 1/2 pathway. Toxicology and Applied Pharmacology, 2019, 368: 1-17.
7. Biao Yan, Zexia Wang, Jiaoe Chen, Lin Zhang, Zihao Cai, Yang Wu, Ping Ma. Role of the necrosis factor-κB pathway in dibutyl phthalate mediated effects on human glioma cells. Toxicological and Environmental Chemistry, 2018, 100(2): 644-657.
8. Biao Yan, Junhui Guo, Xudong Liu, Jinquan Li, Xu Yang, Ping Ma, Yang Wu. Oxidative stress mediates dibutyl phthalate induced anxiety-like behavior in Kunming mice. Environmental Toxicology and Pharmacology, 2016, 45: 45-51.
9. Biao Yan, Jinquan Li, Junhui Guo, Ping Ma, Zhuo Wu, Zhenhao Ling, Hai Guo, Yoshino Hiroshi, U Yanagi, Xu Yang, Shengwei Zhu, Mingqing Chen. The toxic effects of indoor atmospheric fine particulate matter collected from allergic and non-allergic families in Wuhan on mouse peritoneal macrophages. Journal of Applied Toxicology, 2016, 36(4): 596-608.