朱海丽，女，汉族，山西长治人，1981年11月出生。博士，副教授，硕士生导师。致力于神经科学与神经病理学研究，研究成果以第一作者或通讯作者在高水平国际权威期刊发表论文数10篇。研究课题获国家自然科学基金青年项目、面上项目、湖北省自然科学基金项目、湖北省教育厅项目以及湖北科技学院校级项目的资助。

一、科研项目

1. 国家自然科学基金面上项目，81971066，长效缓释激活SIRT1调控线粒体动力学复位线粒体功能抑制骨癌痛的机制研究，2020/01-2023/12，55万元，在研，主持

2. 国家自然科学基金青年项目，81300922，Tau蛋白乙酰化在阿尔茨海默病中的作用和机制研究，2014/01-2016/12，23万元，结题，主持

3. 湖北省自然科学基金面上项目，2019CFB603，SRT1720缓释长效激活SIRT1信号抑制骨癌痛的病理机制研究，2019/01-2020/12，结题，主持

4. 湖北省教育厅青年项目，Q20172804，ASIC3乙酰化修饰在大鼠骨癌痛模型中的作用及其调控机制，2017/01-2018/12，结题，主持

5. 湖北科技学院校级团队项目，2020TD02，突触可塑性改变介导神经系统疾病的机制研究，2020/01-2023/12，5万元，在研，主持

二、代表性论文

1. Yang HY, Zhang F, Cheng ML, Wu J, Xie M, Yu LZ, Liu L, Xiong J, Zhu HL. Glycogen synthase kinase-3β inhibition decreases inflammation and relieves cancer induced bone pain via reducing Drp1-mediated mitochondrial damage. Journal of cellular and molecular medicine, 2022, 26(14):3965-3976.

2. Xie, Min; Cheng, Menglin; Wang, Bojun; Jiao, Ming; Yu, Liangzhu; Zhu, Haili; 2-Bromopalmitate attenuates inflammatory pain by maintaining mitochondrial fission/fusion balance and function., Acta Biochimica et Biophysica Sinica, 2021, 53(1): 72-84

3. Hao Miaomiao; Tang Qiong; Wang Banghua; Li Yisheng; Ding Jieqiong; Li Mingyue; Xie Min; Zhu Haili; Resveratrol suppresses bone cancer pain in rats by attenuating inflammatory responses through the AMPK/Drp1 signaling., Acta biochimica et biophysica Sinica, 2020, 52(3): 231-240

4. Li Mingyue; Ding Jieqiong; Tang Qiong; Hao Miaomiao; Wang Banghua; Wu Ji; Yu Liangzhu; Jiao Ming; Luo Binhua; Xie Min; Zhu Haili; SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission., Biochimica et Biophysica Acta (BBA)-Molecu lar Basis of Disease, 2019, 1865(3): 587-598

5. Meng W, Hao MM, Yu N, Li MY, Ding JQ, Wang BH, Zhu HL, Xie M. 2-Bromopalmitate attenuates bone cancer pain via reversing mitochondrial fusion and fission imbalance in spinal astrocytes. Molecular pain, 2019;15:1744806919871813.

6. Tang Q, Li MY, Yu LZ, Zhu HL. 2-Bromopalmitate Attenuates Bone Cancer Pain by Reducing Expression Levels of Membrane ASIC3 in Dorsal Root Ganglion Neurons[J]. Chinese Journal of Biochemistry and Molecular Biology, 2018, 34(08):884-890

7. Zhu Haili; Ding Jieqiong; Wu Ji; Liu Tingting; Liang Jing; Tang Qiong; Jiao Ming; Resveratrol attenuates bone cancer pain through regulating the expression levels of ASIC3 and activating cell autophagy, Acta Biochimica et Biophysica Sinica, 2017, 49(11): 1008-1014

8. Zhu Haili; Liu Zexu; Huang Yuxin; Zhang Chao; Li Gang; Liu Wei ; Biochemical and structural characterization of MUPP1-PDZ4 domain from Mus musculus, Acta Biochimica et Biophysica Sinica, 2015, 47(3): 199-206

9. Zhu HL, Meng SR, Fan JB, Chen J, Liang Y. Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362. PLoS One. 2011;6(9):e25020.

10. Zhu Haili, Fernández C, Fan JB, Shewmaker F, Chen Jie, Minton AP, Liang Yi. Quantitative characterization of heparin binding to Tau protein: implication for inducer-mediated Tau filament formation. J Biol Chem. 2010, 285(6):3592-3599.